This whitepaper delves into the complexities of Industrial Control Systems (ICS) in modern manufacturing, highlighting the urgent need for robust cybersecurity in the Industry 4.0 era. It discusses the transition from traditional to advanced manufacturing, underscoring the vulnerabilities of ICS and the associated operational threats, including those originating from legacy or multi-vendor environments. The paper emphasizes balancing innovation with risk management in smart manufacturing, and the importance of resilient system strategies that integrate with existing security infrastructures. Additionally, it addresses the necessity for organizations to navigate changing regulatory landscapes in response to escalating cybersecurity threats. The focus shifts towards proactive prevention and secure communication, along with the importance of implementing security measures that are both operationally flexible and compatible. While many organizations have embraced network-based security solutions, mostly focused on detection rather than prevention, only a few recognize the imperative need to directly protect ICS. Lastly, it stresses the alignment of these solutions with recognized OT  cybersecurity best practices and regulations.